QUEEN'S BIOLOGY MCIB SEMINAR SERIES
  • Home
  • Schedule
  • Contact

Seminar series of the Molecular, Cellular & Integrative Biology
research groups at Queen's University

10.04.2016 // Justin Wong, MSc Student, Babak Lab

9/23/2016

 

Chromosomes and bytes of code: A computational genomics approach to identify imprinted genes on the human X chromosome 

Picture
​Humans and other mammals have two sets of chromosomes: one set that is maternally inherited; the other, paternally inherited.  While most genes are evenly expressed, there are cases where one copy of the gene is favoured over the other. We typically think of this happening as one trait or allele being ‘dominant’ over the other. In the case of genomic imprinting, however, gene expression is determined based on parent of origin, rather than gene sequence. This results in asymmetric expression of alleles for traits inherited maternally vs. paternally. Defects in imprinted genes are responsible for a number of diseases such as: Prader-Willi syndrome, Beckwith-Wiedemann syndrome, and Angelman syndrome. To date, there have been no imprinted genes identified on the human X chromosome. This is mainly due to the experimental limitations, as well as the random X inactivation that occurs in humans. With these restrictions in mind, how do we investigate genomic imprinting on the human X chromosome? Can computers and data mining be used to complement next-gen sequencing and traditional molecular techniques?

11:30-12:30 BioSci Rm. 3110


Comments are closed.

    Archives

    February 2021
    January 2021
    December 2020
    November 2020
    October 2020
    September 2020
    August 2020
    June 2020
    April 2020
    March 2020
    February 2020
    January 2020
    November 2019
    October 2019
    September 2019
    August 2019
    July 2019
    May 2019
    April 2019
    March 2019
    February 2019
    January 2019
    November 2018
    October 2018
    September 2018
    June 2018
    May 2018
    April 2018
    March 2018
    February 2018
    January 2018
    November 2017
    October 2017
    September 2017
    June 2017
    May 2017
    April 2017
    March 2017
    February 2017
    January 2017
    December 2016
    November 2016
    October 2016
    September 2016
    August 2016

Powered by Create your own unique website with customizable templates.
  • Home
  • Schedule
  • Contact