QUEEN'S BIOLOGY MCIB SEMINAR SERIES
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Seminar series of the Molecular, Cellular & Integrative Biology
research groups at Queen's University

10.31.2017// Charles Hindmarch, Department of Medicine, Queen's University

10/25/2017

 

Hydromineral homeostasis in mammals: the application of high-thoughput technologies to enhance discovery

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Osmotic stability is aggressively defended in mammalian organisms that must maintain a wet internal environment in a dry external environment; fluids lost through excretion, perspiration or expiration must be replaced quickly. Osmoregulation is a highly conserved mechanism that provides a means by which an organism can maintain a constant prescribed level of water and salts within the intra and extracellular fluid. The path of least resistance here is a behavioural adaptation to replacing water by actively seeking out water. However, since water is not always readily available, this mechanism is complemented by a physiological approach to limit the amount of water lost in times of osmotic stress. Here, I will discuss research using both transcriptomic and physiological tools in order to describe structures within the brain in order to identify the genes that are involved in the business of hydromineral homeostasis.

11:30-12:30 BioSci Rm. 3110
And Free Lunch Meet & Greet 12:30-1 in BioSci 3rd floor lunch room (Rm 3406)

10.24.2017// Julie Brill, University of Toronto, Sickkids

10/19/2017

 

Cell morphogenesis during Drosophila sperm development

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Formation of mature, fertile sperm involves dramatic changes in cell shape and formation of sperm-specific organelles needed for cell motility and fertilization. Spermatogenesis in the fruit fly Drosophila melanogaster is particularly dramatic, as developing sperm become nearly 2 mm long (~50x longer than human sperm) and form needle-shaped nuclei (~10x more condensed than in human sperm) during their differentiation. Drosophila sperm development begins by asymmetric division of a germline stem cell to give rise to a new stem cell and a daughter gonial cell, which divides mitotically and meiotically to produce a cyst of interconnected spermatids that differentiate to form mature sperm. We discovered that a class of membrane lipid signaling molecules, the phosphatidylinositol phosphates, or PIPs, is required for cell morphogenesis and organelle biogenesis at multiple stages of sperm development: PIPs are needed for cytokinesis during male meiosis, for cell polarization during spermatid elongation, for formation of functional sperm tails, and for nuclear shaping. Our ongoing studies will shed light on how PIPs and their regulatory enzymes control these conserved processes, which are important for male fertility.

11:30-12:30 BioSci Rm. 3110
And Free Lunch Meet & Greet 12:30-1:30 in BioSci 3rd floor lunch room (Rm 3406)

10.17.2017// Lois Mulligan, Department of Biomedical and Molecular Sciences, Queen's University

10/13/2017

 

Regulating RET receptor location and function: The tails that wag the oncogenic dog

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Receptor tyrosine kinases link extracellular signals with intracellular pathways that cause cells to move, grow, proliferate or differentiate.  These roles are essential to normal development but can be hijacked in human cancers. My lab is interested in the functions and regulation of the RET receptor tyrosine kinase and its roles in normal development and in the growth and spread of several challenging to manage human cancers.  Our work focuses on how different isoforms of RET contribute differentially to these processes, and how the localization and intracellular paths taken by these isoforms affect their contributions.

11:30-12:30 BioSci Rm. 3110
And Free Pizza Meet & Greet 12:30-1:30 in BioSci 3rd floor lunch room (Rm 3406)

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