Regulating RET receptor location and function: The tails that wag the oncogenic dog
Receptor tyrosine kinases link extracellular signals with intracellular pathways that cause cells to move, grow, proliferate or differentiate. These roles are essential to normal development but can be hijacked in human cancers. My lab is interested in the functions and regulation of the RET receptor tyrosine kinase and its roles in normal development and in the growth and spread of several challenging to manage human cancers. Our work focuses on how different isoforms of RET contribute differentially to these processes, and how the localization and intracellular paths taken by these isoforms affect their contributions.
11:30-12:30 BioSci Rm. 3110