Dr. Matthew Pamenter, Dept. Biology, University of Ottawa
I am interested in the physiological and related molecular mechanisms that underlie natural metabolic adaptations to low oxygen stress and enable central nervous system function and viability in hypoxia and ischemia. Specifically, I use hypoxia-tolerant comparative model organisms (African mole rats, western painted turtles, goldfish) and oxygen-sensitive mammalian cells and tissues (mouse, human) to investigate cellular and systemic mechanisms involved in hypoxia-tolerance and neuroprotection. The long-term aim of my research is to discover cellular pathways and molecular candidates that enable endogenous systemic tolerance to low oxygen stress in hypoxia-adapted species, and to translate these mechanisms to hypoxia-intolerant mammals in order to reduce or reverse brain cell injury caused by pathological conditions that compromise oxygen supply to the tissue (e.g. stroke, heart attack, COPD, etc). Comments are closed.
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February 2021
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